We have a family of potentials $V_t$ on $\mathbb{R}^n$, evolving with time, and their associated Gibbs measures $p_t$, ie

$\begin{aligned} &p_t(x) = \frac{e^{-V_t(x)}}{Z_t}&& \text{where}&& Z_t = \int_{\mathbb{R}^n} e^{-V_t(x)}dx.\end{aligned}$The goal is to compute, at least numerically, the partition functions $Z_t$ or equivalently the free energy $F_t = - \log Z_t$. In many problems, the family of potentials $(V_t)$ connects an unknown potential $V_0$, for which we would like to compute $F_0$, and another potential $V_1$ for which $F_1$ is known.

An elegant way of estimating these free energies uses the *Jarzynski identity*, discovered in 1996. It is based on the Langevin dynamics associated with the evolving potential $V_t$:

with $(W_t)$ a Brownian motion. Upon standard conditions on $V_t$, this system – a standard Stochastic Differential Equation – has a solution. Note that the distribution of $X_t$ is *not* $p_t$ in general. However, there is a remarkable identity relating the distribution of $X_t$ with $p_t$.

**Jarzynski's identity** states that

Here and after, the dot in $\dot{V}_t$ or $\dot{F}_t$ always represents a derivative with respect to time.

The consequence of this identity is that

$\log \mathbf{E}[e^{-\int_0^t \dot{V}_s(X_s)ds}] = F_t - F_0,$giving rise to a natural estimator for the *free energy difference* $F_t-F_0$: one samples many paths from the dynamics (2), then computes the path integral $w_t = \int_0^t \dot{V}_s(X_s)ds$ along each path, and then average the values of $e^{-w_t}$ and take the log.

In general, exponential of paths integrals are not easy to study. The classical way is to use the Feynman-Kac representation of PDEs, but this proof seems quite involved; instead, there is a nice trick shown to me by Eric Vanden-Eijnden. The trick is as follows: if $\rho_t(x,y)$ is the probability density of the system $(X_t, e^{-\int_0^t \dot{V}_s(X_s) - \dot{F}_sds})$ at $t$, then

clearly, we want to compute $\int u \rho_t(x,u)dudx$,

the quantity $a_t(x) = \int u \rho_t(x,u)du$ solves an explicit equation,

and from this equation we can see that $a_t(x) = e^{-V_t(x)}/Z_t = p_t(x)$.

The proof is then finished, since $\int a_t = \int p_t = 1$. From now on, we'll set $U_t = V_t - F_t$, so that $p_t(x) = e^{-U_t(x)}$. Clearly, $\nabla U_t = \nabla V_t$.

We set

$\begin{cases}dX_t = - \nabla U_t(X_t)dt + \sqrt{2}dW_t \\ dI_t = -\dot{U}_t(X_t)I_t\end{cases}$subject to the starting condition $I_0=1$ and $X_0 \sim p_0$. Then clearly,

$I_t = e^{-\int_0^t \dot{U}_s(X_s)ds}.$We consider the system $Z_t= (X_t, I_t)$ as a single SDE $d Z_t = f(t,Z_t)dt + \sigma dW_t$ with

$\begin{aligned}&f_t(x,y) = \begin{pmatrix} - \nabla U_t(x) \\ -\dot{U}_t(x)y \end{pmatrix} &&\text{ and }&& \sigma = \mathrm{diag}(\sqrt{2}, \dotsc, \sqrt{2}, 0).\end{aligned}$Let us note $\rho_t(x,y)$ the density of $(X_t, I_t)$, and write the associated Fokker-Planck equation; here and after, $\nabla$ is a gradient and $\nabla \cdot$ is the divergence, ie $\nabla \cdot \varphi = \sum_i \partial_i \varphi$. Subscripts denote partial differentiation with respect to some variables.

$\begin{aligned}\dot{\rho}_t &= -\nabla \cdot \left[ f_t\rho_t \right] + \frac{\sigma^2}{2}\Delta \rho_t\\ &= - (\nabla \cdot f_t) \rho_t - f_t \cdot \nabla \rho_t + \Delta_x \rho_t \\ &= - (\nabla_x \cdot f_t) \rho_t - (\nabla_y \cdot f_t)\rho_t - f_t \cdot \nabla \rho_t + \Delta_x \rho_t \\ &=- (\nabla \cdot \nabla U_t) \rho_t + \dot{U}_t\rho_t - f_t \cdot \nabla \rho_t + \Delta_x \rho_t\\ \end{aligned}$Set $a_t(x) = \int_0^\infty y \rho_t(x,y)dy$, so that $\mathbf{E}[I_t] = \int a_t(x)dx$. Multiplying the last equation by $y$, integrating, and swapping integrals and derivatives, we get

$\begin{aligned}\dot{a}_t &= \int y \dot{\rho}_t(x,y)dy \\ &= - (\nabla \cdot \nabla U_t) a_t + \dot{U}_t a_t - \int y (f_t \cdot \nabla \rho_t) + \Delta a_t \end{aligned}$We have $f_t \cdot \nabla \rho_t = - \nabla U_t \cdot \nabla_x \rho_t - \dot{U}_t y \nabla_y \rho_t$, hence

$\dot{a}_t = - (\nabla \cdot \nabla U_t) a_t + \dot{U}_t a_t + \nabla U_t \cdot \nabla a_t + \dot{U}_t \int y^2 \partial_y \rho_t(x,y)dy+ \Delta a_t.$An integration by parts shows that $\int y^2 \partial_y \rho_t(x,y)dy = -2 \int y \rho_t(x,y)dy = -2a_t$, providing a sufficient decay of $y \to y^2 \rho(x,y)$ at infinity. We obtain the following equation:

$\dot{a}_t = -(\nabla \cdot \nabla U_t)a_t - \dot{U}_t a_t + \nabla U_t \cdot \nabla a_t + \Delta a_t.$It turns out that the density $p_t(x) = e^{-U_t(x)}$ is the solution of this equation. Indeed, $p_t = - \dot{U}_t p_t$ and $\nabla p_t = -\nabla U_t p_t$, so that it is easy to check that (11) is satisfied. Moreover, $a_0(x)= \int y \rho_0(x,y)dy = e^{-U_0(x)} = p_0(x)$, so the initial conditions are identical.

To conclude, we obtain

$\mathbf{E}[I_t] = \int a_t(x)dx = \int p_t(x)dx = 1.$Jarzynski's paper, written in 1996.